Endocrine Abstracts

Mineralocorticoid Receptor (MR) is able to regulate the transcription of a number of genes in the myotube, nevertheless the role of this steroid hormone receptor in skeletal muscle (SM) metabolism needs to be clarified. SM represents a major site for glucose uptake and local metabolic derangements play a pivotal role in the development of insulin resistance (IR). The aim of this study was to investigate the contribution of MR in mediating SM metabolic alterations in a mouse mo...

Objective: higher aldosterone (aldo) levels are associated with increased risk of cardiovascular ischemic events and mortality. It has been demonstrated that aldo accelerates the development of aterosclerosis in apolipoprotein E knockout mice (ApoE KO). Ketogenic diet (KD) positively impacts several cardiovascular risk factors, yet its effect on atherosclerosis, is elusive. We hypothesize that, KD protects from development of atherosclerotic plaques in ApeE KO mice, a murine m...

Metabolic Syndrome (MetS) is characterized by the association of insulin resistance, hypertension, dyslipidemia, non-alcoholic fatty liver disease, and is strictly related to increased cardiovascular risk. Recent scientific evidence confirms that very low calorie ketogenic diet (VLCKD) is a valuable treatment for patients with insulin resistance and visceral obesity. After the VLCKD phase it is essential to gradually reintroduce carbohydrates and increase calories in order to ...

Drospirenone (DRSP) is a potent antimineralocorticoid with progestative and moderate antiandrogenic properties. We have previously shown that DRSP exerts a potent antiadipogenic activity in murine and human preadipocytes through specific antagonism of the MR. In the present study responses to DRSP were investigated in a model of diet-induced obesity for 12 weeks. Female 10-week-old C57bl6 mice were fed with normal chow or a high fat diet (HF, containing 45% fat by calories). M...